Risk factors of vertebral fractures in women with systemic lupus erythematosus

@article{MendozaPinto2009RiskFO,
  title={Risk factors of vertebral fractures in women with systemic lupus erythematosus},
  author={Claudia Mendoza-Pinto and Mario Garc{\'i}a-Carrasco and Hilda Sandoval-Cruz and Margarita Mu{\~n}{\'o}z-Guarneros and Ricardo O Esc{\'a}rcega and Mario Jim{\'e}nez-Hern{\'a}ndez and Pamela Mungu{\'i}a-Realpozo and M. V. H. Sandoval-Cruz and Margarita Delez{\'e}-Hinojosa and Aurelio L{\'o}pez-Colombo and Ricard Cervera},
  journal={Clinical Rheumatology},
  year={2009},
  volume={28},
  pages={579-585},
  url={https://api.semanticscholar.org/CorpusID:29786198}
}
Age and low bone mineral density at the total hip remained as significant factors for the presence of vertebral fracture in women with SLE, implying that more attention must be paid to detect and treat vertebral fractures.
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61 Citations

Prevalence and risk factors of vertebral compression fractures in female SLE patients

Radiological compression fractures are common but seldom diagnosed in SLE patients, and high age and low BMD in total hip, but not in spine, was associated with vertebral fractures.

Prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus

The high prevalence of vertebral fracture in SLE patients indicates that more female Japanese SLE Patients regardless of BMD and use of corticosteroids need to be assessed, although additional studies are warranted to confirm the findings suggested in this study.

Prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus

The high prevalence of vertebral fracture in SLE patients indicates that the lateral spine radiograph needs to be assessed in more female Japanese Sle patients regardless of BMD and use of corticosteroids, although additional studies are warranted to confirm the findings suggested.

Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up

In this SLE cohort in daily clinical practice, new VF were frequently present in SLE patients, especially those with longer disease duration and low-hip BMD, and significantly associated with baseline BMD at the total hip and longer diseaseduration.

Assessment of fracture risk in a cohort of Egyptian female Systemic Lupus erythematosus patients

Systemic lupus erythematosus and fractures

A 6-year follow-up study on Dutch patients with SLE revealed that low 25-hydroxyvitamin D serum levels, low body mass index and baseline use of antimalarials were associated with bone loss, and a dose-dependent relationship between glucocorticoid use and bone loss was demonstrated in longitudinal studies in SLE.

Prevalence and associated factors of low bone mass in adults with systemic lupus erythematosus

The prevalence of low BMD is high in SLE patients, and is associated with older age and higher cumulative glucocorticoid dose, and age and cumulative dose of glucocorts are statistically significantly associated with abnormal BMD in multivariate analysis.

Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls

A 2.964-fold increased risk of osteoporotic fracture in SLE patients compared to age- and sex-matched non-SLE controls is found and male or middle-aged SLE Patients had a relatively higher fracture risk among patients with SLE.

Incidence of and risk factors for non-vertebral and vertebral fracture in female Chinese patients with systemic lupus erythematosus: a five-year cohort study

The incidence of fracture in SLE patients is lower than the prevalence reported in cross-sectional studies, and lumbar spine BMD appears to have a stronger relationship with incident fracture than hip BMD, which warrants further investigation regarding the optimal site of BMD measurement when predicting fracture risk in Sle patients.

Prevalence of fractures in women with rheumatoid arthritis and/or systemic lupus erythematosus on chronic glucocorticoid therapy

It is of utmost importance that women chronically using GCs are assessed for fractures, including morphometric vertebral fractures, which have higher 10-year probabilities of major osteoporotic fractures and worse quality-of-life and increased fracture risk.
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25 References

Prevalence of and risk factors for low bone mineral density and vertebral fractures in patients with systemic lupus erythematosus.

The high prevalence of low BMD and vertebral fractures implies that more attention must be paid to the prevention and treatment of osteoporosis and fractures in SLE.

High prevalence of vertebral deformity in premenopausal systemic lupus erythematosus patients

Although BMD could not predict what patient have deformity, seven patients with deformity had a lumbar spine or femoral neck Z-score less than -1 SD, which brings up the necessity to look for spine deformities in this group of women regardless of the BMD.

Risk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritis.

It is concluded that patients with steroid treated RA may have abnormal bone quality, and that LS-BMD cannot be used to predict the risk of vertebral fracture in these patients.

Vertebral fracture epidemiology.

Vertebral Fractures Predict Subsequent Fractures

Data show that vertebral fractures represent an important risk factor for fractures in general, not just those of the spine and hip, as well as whether the initial vertebral fracture was attributed to severe or moderate trauma.

High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a cross-sectional outpatient study.

Vertebral fracture risk with long-term corticosteroid therapy: prevalence and relation to age, bone density, and corticosteroid use.

The combination of increasing age and corticosteroid use is associated with a marked increase in the risk of vertebral deformity and Elderly patients commencing long-term cortiosteroid therapy should be considered for antiosteoporotic therapy independently of their BMD.

Corticosteroids Do Not Alter the Threshold for Vertebral Fracture

The results fail to support the notion that the fracture threshold is altered in patients on long‐term steroids and suggest that the same diagnostic criteria should be used for osteoporosis in patients whether or not they are taking corticosteroid therapy.

The prevalence of radiographic vertebral fractures in Latin American countries: the Latin American Vertebral Osteoporosis Study (LAVOS)

It is concluded that radiographically ascertained vertebra fractures are common in Latin America and health authorities in the region should be aware and consider implementing measures to prevent vertebral fractures.

Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: A 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study

It is concluded that prevalent vertebral deformity could be used as a risk factor in both genders for mortality and future fracture in both men and women.