Type VI secretion is a major virulence determinant in Burkholderia mallei

@article{Schell2007TypeVS,
  title={Type VI secretion is a major virulence determinant in Burkholderia mallei},
  author={Mark A. Schell and Ricky L. Ulrich and Wilson J. Ribot and Ernst E. Brueggemann and Harry B. Hines and Dan Chen and Lyla Lipscomb and H. Stanley Kim and Jan Mr{\'a}zek and William C. Nierman and David DeShazer},
  journal={Molecular Microbiology},
  year={2007},
  volume={64},
  url={https://api.semanticscholar.org/CorpusID:25690886}
}
It is shown with expression profiling that overexpression of virAG resulted in transcriptional activation of ∼60 genes, including some involved in capsule production, actin‐based intracellular motility, and type VI secretion (T6S) in hamsters, and BMAA0742 was secreted by the T6S system when virAG was overexpressed.
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337 Citations

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73 References

Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinant.

The results presented here demonstrate that the capsular polysaccharide of B. mallei is required for production of disease in two animal models of glanders infection and is a major virulence factor.

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Findings demonstrate that B. mallei carries multiple luxIR homologues that either directly or indirectly regulate the biosynthesis of an essential virulence factor(s) that contributes to the pathogenicity of B.mallei in vivo.

The Animal Pathogen-Like Type III Secretion System Is Required for the Intracellular Survival of Burkholderia mallei within J774.2 Macrophages

It is demonstrated that this bacterial protein delivery system is required for intracellular growth of B. mallei in J774.2 cells, formation of macrophage membrane protrusions, actin polymerization, and phagosomal escape.

Identification of a bacterial factor required for actin‐based motility of Burkholderia pseudomallei

It is reported that purified truncated BimA protein binds monomeric actin in a concentration‐dependent manner in cosedimentation assays and that BIMA stimulates actin polymerization in vitro in a manner independent of the cellular Arp2/3 complex.

Type III Secretion: a Virulence Factor Delivery System Essential for the Pathogenicity of Burkholderia mallei

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CmeABC Functions as a Multidrug Efflux System in Campylobacter jejuni

It is formally established that CmeABC functions as a tripartite multidrug efflux pump that contributes to the intrinsic resistance of C. jejuni to a broad range of structurally unrelated antimicrobial agents.

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The data suggest that divergent evolution of a small set of genes, rather than acquisition or loss of pathogenic islands, is associated with the development of different life styles in these bacteria of similar genomic contents.

Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system

It is shown that vas genes are required for cytotoxicity of V. cholerae cells toward Dictyostelium amoebae and mammalian J774 macrophages by a contact-dependent mechanism, and it is proposed that these genes encode a prototypic “type VI” secretion system.

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Two possible secretion systems (TTSS and Evp) that are vital for E. tarda pathogenesis are identified and similar gene clusters are widely distributed in other pathogens such as Escherichia, Salmonella, Vibrio and Yersinia species with unknown functions.
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